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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Creating a data commons: The INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT).

Kirk D Wyatt1, Suzi Birz2, Douglas S Hawkins3

  • 1Division of Pediatric Hematology/Oncology, Roger Maris Cancer Center, Sanford Health, Fargo, North Dakota, USA.

Pediatric Blood & Cancer
|August 15, 2022
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Summary
This summary is machine-generated.

The International Soft Tissue Sarcoma Consortium (INSTRuCT) advances pediatric soft tissue sarcoma research. It fosters global collaboration to address key challenges and priorities in treating these rare childhood cancers.

Keywords:
data aggregationpediatricssarcoma

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Area of Science:

  • Pediatric Oncology
  • Sarcoma Research
  • Clinical Collaboration

Background:

  • Pediatric soft tissue sarcomas, including rhabdomyosarcoma and non-rhabdomyosarcoma types, represent a significant area of clinical research.
  • Current research faces challenges in data sharing, resource allocation, and coordinated therapeutic development.
  • International collaboration is crucial for advancing understanding and treatment of these rare pediatric malignancies.

Purpose of the Study:

  • To detail the establishment and objectives of the International Soft Tissue Sarcoma Consortium (INSTRuCT).
  • To outline INSTRuCT's strategy for addressing critical research priorities in pediatric soft tissue sarcoma.
  • To promote enhanced international research and collaboration in the field.

Main Methods:

  • The article describes the genesis and evolution of the INSTRuCT initiative.
  • It outlines the consortium's approach to identifying and tackling key research challenges.
  • Methods involve fostering global partnerships and shared research agendas.

Main Results:

  • INSTRuCT has been established to unify international efforts in pediatric soft tissue sarcoma research.
  • The consortium aims to streamline research by focusing on identified priorities.
  • Progress involves building a collaborative network for future studies.

Conclusions:

  • The International Soft Tissue Sarcoma Consortium (INSTRuCT) is poised to significantly impact pediatric soft tissue sarcoma research.
  • By fostering international collaboration, INSTRuCT will accelerate progress in understanding and treating these cancers.
  • Addressing research priorities through a unified global approach is essential for improving outcomes for affected children.