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ELANE neutropenia and solid tumors: Four cases from the French severe chronic neutropenia registry
Jean Donadieu1, Fares Bou Mitri1, Blandine Beaupain1
1French Registry for Severe Chronic Neutropenia, Armand-Trousseau Hospital, APHP, Paris, France.
Abstract:
Neutropenia related to ELANE gene mutations predisposes patients to infection and leukemia/myelodysplasia, but little is known about the predisposition to cancer. Among a cohort of 147 patients, we identified four with malignant solid tumors (papillary thyroid cancer, anal squamous cell cancer, papillary renal cell carcinoma, and adrenocortical carcinoma), all aged 25-50 years. Three occurred with cyclic neutropenia, and one occurred with severe chronic neutropenia. Previous radiotherapy was identified as a risk factor in one patient. No genetic predisposition was identified in the three other patients.
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