The predictive value of MAPH score for determining thrombus burden in patients with non-ST segment elevation...

Area of Science:

• Cardiology
• Hematology
• Biomedical Engineering

Background:

• High thrombus burden is linked to adverse outcomes in non-ST segment elevation myocardial infarction (NSTEMI).
• The MAPH score's predictive value for thrombus burden in NSTEMI is not well-established.
• This study investigates the MAPH score's prognostic role in estimating coronary thrombus burden in NSTEMI patients.

Purpose of the Study:

• To evaluate the prognostic role of the MAPH score in estimating coronary thrombus burden in NSTEMI patients.
• To determine if the MAPH score can predict high thrombus burden (HTB) in NSTEMI.
• To assess the relationship between MAPH score, low shear rate (LSR), and high shear rate (HSR) with thrombus burden.

Main Methods:

• Patients were categorized into low and high thrombus burden groups.
• Low shear rate (LSR) and high shear rate (HSR) were estimated using hematocrit and serum total protein levels.
• The MAPH score was calculated by summing mean platelet volume (MPV), age, total protein, and hematocrit.

Main Results:

• Patients with high thrombus burden exhibited higher LSR, HSR, and MAPH scores.
• The MAPH score independently predicted high thrombus burden in both adjusted models (Model 1: OR 1.124; Model 2: OR 1.236).
• A MAPH score cutoff of 2 was identified for predicting high thrombus burden.

Conclusions:

• The MAPH score, incorporating MPV, age, total protein, and hematocrit, is a novel and accessible predictor.
• The MAPH score is an independent predictor of high thrombus burden in NSTEMI patients under both LSR and HSR conditions.