Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

External and Internal Respiration01:24

External and Internal Respiration

4.6K
External respiration occurs in the lungs, and it is the first step in the journey of oxygen inside the body. When we inhale, oxygen enters our lungs and diffuses across the thin alveolar membrane. The alveoli are tiny, air-filled sacs that provide a vast surface area for gas exchange. Oxygen in the alveoli has a higher partial pressure (105 mmHg) than in the adjacent pulmonary capillaries (40 mmHg), establishing a pressure gradient. As a result, oxygen molecules move from the alveoli into the...
4.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.0K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

284
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
284
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension.

bioRxiv : the preprint server for biology·2026
Same author

Standardising terminology in routine electronic health records for respiratory endpoints: why we still can't agree.

Thorax·2026
Same author

Longitudinal study of changes in walking and cognition by motor subtype of Parkinson's disease.

Parkinsonism & related disorders·2026
Same author

Z-scores for Spirometry Interpretation: Implications for Classifying Impairments in Lung Function.

Annals of the American Thoracic Society·2026
Same author

Skeletal muscle-specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice.

Experimental physiology·2026
Same author

Single-cell Sequencing Unveils A Profibrotic Macrophage and Infiltrating Monocyte Niche in the Bronchoalveolar Lavage of Patients with Chronic Obstructive Pulmonary Disease.

American journal of respiratory and critical care medicine·2026
Same journal

Higher BMI is associated with greater fatigue and dyspnea in interstitial lung disease: a Pulmonary Fibrosis Foundation Registry study.

Annals of the American Thoracic Society·2026
Same journal

Social Drivers in COPD: Securing Better Outcomes May Start with Food.

Annals of the American Thoracic Society·2026
Same journal

Blood Pressure Change After Six-minute Walk Test Is an Independent Predictor of Clinical Worsening in Patients with Pulmonary Hypertension.

Annals of the American Thoracic Society·2026
Same journal

Co-designing a Palliative Care Referral Tool for Patients with Fibrosing Interstitial Lung Disease.

Annals of the American Thoracic Society·2026
Same journal

Use of the Wnt/β-catenin Activator Lithium Is Associated with Less Emphysema.

Annals of the American Thoracic Society·2026
Same journal

Housing mobility program effects on ambient fine particulate matter exposure and childhood asthma morbidity.

Annals of the American Thoracic Society·2026
See all related articles

Related Experiment Video

Updated: Sep 1, 2025

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.7K

Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease.

Aparna Balasubramanian1, Nirupama Putcha1, Neil R MacIntyre2

  • 1Division of Pulmonary & Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.

Annals of the American Thoracic Society
|August 15, 2022
PubMed
Summary
This summary is machine-generated.

Diffusing capacity of the lung for carbon monoxide (Dlco) strongly predicts mortality in COPD patients. Adding Dlco to the BODE index improves the accuracy of mortality risk prediction in individuals with chronic obstructive pulmonary disease.

Keywords:
COPDmortalitypulmonary diffusing capacitypulmonary gas exchange

More Related Videos

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

821
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.1K

Related Experiment Videos

Last Updated: Sep 1, 2025

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.7K
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

821
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.1K

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Clinical Epidemiology

Background:

  • The BODE index (body mass index, obstruction, dyspnea, exercise capacity) is commonly used to estimate mortality risk in chronic obstructive pulmonary disease (COPD).
  • Diffusing capacity of the lung for carbon monoxide (Dlco) measures gas transfer and may offer distinct prognostic information not captured by the BODE index.

Purpose of the Study:

  • To evaluate the utility of Dlco as an independent predictor of all-cause mortality in individuals with COPD.
  • To assess whether Dlco improves the discriminative accuracy of existing prognostic models, such as the BODE index.

Main Methods:

  • Time-to-event analyses were conducted on 2,329 participants with COPD from the COPDGene study who had Dlco measurements.
  • Cox proportional hazard models were used to assess mortality risk, adjusting for clinical factors, BODE index components, and computed tomography (CT) findings (emphysema, airway wall thickness).
  • C statistics were calculated to compare the discriminative accuracy of models with and without Dlco.

Main Results:

  • During a median follow-up of 4.9 years, 393 (16.8%) participants died.
  • A 10% decrease in Dlco predicted a 28% increase in mortality risk (hazard ratio = 1.28, P < 0.001), independent of other factors.
  • Dlco demonstrated prognostic performance comparable to the BODE index (C-statistic 0.68 vs. 0.70), and its addition to the BODE index improved overall discriminative accuracy (C-statistic 0.71).

Conclusions:

  • Diffusing capacity of the lung for carbon monoxide (Dlco) is a significant independent predictor of all-cause mortality in COPD patients.
  • Dlco provides prognostic information beyond the BODE index and CT-derived measures of emphysema and airway disease.
  • These findings support the integration of Dlco measurements into comprehensive prognostic models for COPD management.