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Related Experiment Videos

Baclofen in hemifacial spasm.

R Sandyk, M A Gillman

    The International Journal of Neuroscience
    |April 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Baclofen effectively treated six patients with idiopathic hemifacial spasm resistant to other medications. Piracetam managed the sole adverse effect, suggesting baclofen

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Idiopathic hemifacial spasm (IHS) is a neurological disorder characterized by involuntary facial muscle contractions.
    • Standard pharmacological treatments for IHS often prove ineffective in refractory cases.

    Purpose of the Study:

    • To evaluate the efficacy of baclofen in patients with idiopathic hemifacial spasm refractory to conventional therapies.
    • To explore the potential role of stress in IHS and its response to baclofen.

    Main Methods:

    • A case series involving six patients with refractory idiopathic hemifacial spasm.
    • Treatment with baclofen, with piracetam administered for adverse effects.

    Main Results:

    • Successful treatment of all six patients with baclofen.

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  • One patient experienced memory loss, which was resolved with piracetam.
  • A potential association between stress and IHS, responsive to baclofen, was observed.

    • Conclusions:

    • Baclofen is a viable treatment option for idiopathic hemifacial spasm refractory to other medications.
    • Piracetam can effectively manage baclofen-induced memory loss.
    • Stress may be a contributing factor in some IHS cases, indicating potential therapeutic benefit from baclofen.