The intergenerational persistence of opioid dependence: Evidence from administrative data
Alexander Ahammer1,2, Martin Halla1,2,3,4
1Department of Economics, Johannes Kepler University, Linz, Austria.
Health Economics
|August 15, 2022
Summary
Opioid dependence can persist across generations. Parental opioid use, both illicit and prescription, significantly increases a child's risk of developing opioid dependence, even when accounting for environmental factors.
Area of Science:
- Public Health
- Epidemiology
- Sociology
Background:
- The opioid crisis remains a significant public health challenge.
- Understanding the origins and transmission of opioid dependence is critical for effective interventions.
Purpose of the Study:
- To investigate the intergenerational persistence of opioid dependence.
- To quantify the association between parental opioid use and child opioid dependence.
Main Methods:
- Utilized administrative data from all Austrian births between 1984 and 1990.
- Analyzed prescription opioid use and a novel proxy for illicit opioid dependence.
- Controlled for environmental variables to assess the stability of observed associations.
Main Results:
- Parental illicit opioid use increased child opioid use likelihood from 1% to 7%.
- Parental prescription opioid use increased child opioid use likelihood from 3.6% to 6.7%.
- These associations remained robust after controlling for environmental factors.
Conclusions:
- Evidence suggests a strong intergenerational component to opioid dependence.
- Parental opioid use is a significant risk factor for child opioid dependence, independent of environmental influences.
Keywords:
addictiondrug abuseheroinillicit opioidsintergenerational correlationintergenerational transmissionopioidsprescription opioidsMore Related Videos
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
410
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
410
Analgesia and Pain Management
776
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
776
Opioid Analgesics: Morphine and Other Natural Cogeners
350
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
350
Drug Dependence
1.1K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.1K
Drug Abuse and Addiction: Pharmacological Phenomena
636
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
636
Analysis of Population Pharmacokinetic Data
371
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
371


