"Nano Killers" Activation by permonosulfate enables efficient anaerobic microorganisms disinfection

The development of effective nanomaterials for killing anaerobic bacteria is essential for human health and economic development. Here, we propose a new bactericidal mechanism where theoretical calculations are in good agreement with experimental results. The "poison arrow-head" of MoS₂ nanosheets enables the vigorous extraction of lipids from the cell membrane. Based on density functional calculations, oxidation active species (OAS) are generated due to the strong adsorption energy between S vacancies in MoS₂ and chemical substrates (permonosulfate (PMS) and H₂O). These OAS can be visualized as numerous moving "nano killers", constantly oxidizing the lipids around MoS₂; thereby, re-releasing the surface of the sharp knife. The process of physical extraction collaborated with chemical oxidation not only precisely positions the cell membrane but also allows for continuous sterilization. This work digs into the mechanism of anaerobic bacterial sterilization, which sheds significant light on biological analysis, antibacterial, cancer therapy, and anti microbiologically influenced corrosion.