Related Experiment Video
Updated: Sep 1, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Acute disease induced cognitive dysfunction in older patients - an unrecognized syndrome
Rainer Wirth1, Christiane Nicola Klimek1, Gero Lueg1
1Department of Geriatric Medicine, Marien Hospital Herne, Ruhr University Bochum, Hölkeskampring 40, D- 44625, Herne, Germany.
Background:
It is unknown, how many older hospitalized patients experience cognitive changes independently from delirium.
Methods:
In this retrospective study, cognitive function was assessed with the Montreal Cognitive Assessment on admission and discharge in 103 acute care geriatric hospital patients.
Results:
Mean age was 80.8 ± 7.3 years. The total MoCA score on admission was 17.8 (±4.5) and at discharge 17.7 (±4.4). The mean difference of the total MoCA score was - 0.1 (±3.5). 12 (11.7%) patients suffered from delirium. 46 (44.7%) patients experienced significant changes of cognitive function <- 2 or > 2 MoCA points without delirium. There was no significant association between delirium during hospital stay and the prevalence and magnitude of changes in total MoCA score.
Conclusion:
Cognitive changes frequently occur during acute disease of geriatric patients independently from delirium. We propose the term "acute disease induced cognitive dysfunction" (ADICD) for this entity.
Trial Registration:
German Clinical trial register (DRKS-ID: DRKS00025157 on 28.04.2021).
More Related Videos
Related Concept Videos
Cognitive Development During Adulthood
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Dementia
The progression of dementia is generally gradual....
Alzheimer's Disease: Treatment
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

