Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

55.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.7K
Immunological Memory01:23

Immunological Memory

3.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
3.7K
Long-term Depression01:05

Long-term Depression

31.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
31.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

656
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
656
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.1K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.1K
Traumatic Memory01:20

Traumatic Memory

163
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
163

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community Health Workers' Roles and Challenges in Wisconsin: A Mixed-Methods Study.

Journal of community health·2026
Same author

Rare Case of Ethmoidal Encephalocele and Sequelae.

Clinical practice and cases in emergency medicine·2026
Same author

Perceptions of secure text messaging systems: a cross-sectional survey of hospitalist physicians and advanced practice providers.

Postgraduate medicine·2026
Same author

Heat Stress and Non-Traditional Chronic Kidney Disease (CKDnt) Among Nepali Migrant Workers: A Climate-Sensitive Global Health Perspective.

Cureus·2026
Same author

Sponsorship: A Vital Leadership Strategy for Career Advancement in Academic Medicine.

WMJ : official publication of the State Medical Society of Wisconsin·2026
Same author

A Case of Autoimmune Thyroiditis Presenting as Apraxia.

WMJ : official publication of the State Medical Society of Wisconsin·2026

Related Experiment Video

Updated: Sep 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K

Lingering Effects: Hashimoto's Encephalopathy.

Parker Foster1, Taylor Craig2, Pinky Jha1

  • 1Internal Medicine, Medical College of Wisconsin, Wauwatosa, USA.

Cureus
|August 16, 2022
PubMed
Summary

Hashimoto's encephalopathy (HE), a rare autoimmune disorder, can cause prolonged cognitive issues and frequent relapses. This case shows HE may have a protracted disease course despite treatment.

Keywords:
hashimoto’s encephalitishashimoto’s encephalopathylong term complicationlong-term follow uprare autoimmune disease

More Related Videos

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.2K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.4K

Related Experiment Videos

Last Updated: Sep 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.2K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.4K

Area of Science:

  • Neurology
  • Immunology
  • Endocrinology

Background:

  • Hashimoto's encephalopathy (HE), or steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), is a rare autoimmune neurological disorder.
  • The pathophysiology and clinical course of HE remain incompletely understood, presenting diagnostic and therapeutic challenges.

Observation:

  • A patient presented with multiple comatose relapses early in the disease progression of Hashimoto's encephalopathy.
  • Despite receiving prolonged corticotherapy, the patient exhibited persistent cognitive deficits.

Findings:

  • This case illustrates that Hashimoto's encephalopathy can have a protracted and relapsing clinical course.
  • Cognitive impairments may persist even after extended treatment with corticosteroids.

Implications:

  • The findings underscore the need for long-term monitoring and management strategies for patients with Hashimoto's encephalopathy.
  • Further research is warranted to elucidate the long-term prognosis and optimize treatment protocols for this rare autoimmune condition.