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Aberrant gastric functioning in weight-restored but not acute restricting-type anorexia nervosa: An
Kara L Kerr1,2, Danielle C DeVille3,4, Scott E Moseman5
1Department of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
The International Journal of Eating Disorders
|August 16, 2022
Summary
Individuals with anorexia nervosa (AN) show altered gastric activity after weight restoration, suggesting gastrointestinal (GI) dysfunction may play a role in the eating disorder. Further research into GI functioning in AN is warranted.
Area of Science:
- Gastroenterology
- Psychiatry
- Eating Disorders
Background:
- Anorexia nervosa (AN) is associated with high rates of gastrointestinal (GI) symptoms and functional GI disorders.
- Alterations in interoception are also noted in individuals with AN.
- The role of gastric physiology in AN remains under investigation.
Purpose of the Study:
- To compare gastric physiology, measured by electrogastrography (EGG), between individuals with AN and healthy controls.
- To examine changes in EGG activity in individuals with AN from pre- to post-weight restoration.
Main Methods:
- Adolescent and young adult females with restricting-type AN (n=20) and healthy controls (n=21) underwent two EGG sessions.
- EGG measurements were taken in a fasting state and after a water load.
- Participants with AN completed sessions while underweight and after weight restoration; controls completed matched sessions.
Main Results:
- Individuals with AN showed decreased normogastria post-water load after weight restoration compared to when underweight.
- Gastric EGG measures in healthy controls remained stable across sessions.
- Aberrant gastric physiology was observed in weight-restored individuals with AN, but not in the acute phase.
Conclusions:
- Findings suggest abnormal gastric physiology in individuals with AN following weight restoration.
- These results highlight the potential contribution of GI dysfunction to AN.
- Further research into GI functioning in AN is crucial for understanding and treating the disorder.
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