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Published on: August 27, 2019
Molecular epidemiology of Akabane virus in Taiwan
Hau-You Tzeng1, Cheng-Lung Tsai1,2, Lu-Jen Ting3
1Department of Entomology, National Chung Hsing University, Taichung City, Taiwan.
Background:
Akabane virus (AKAV) is a teratogenic and neuropathogenic arbovirus that infects livestock and wild animals. AKAVs are endemic arboviruses from dairy farms in Taiwan in 1989, and the first sequence was detected in cattle with nonsuppurative encephalitis in 1992.
Objectives:
This study aims to understand the epidemiological relationships of the akabane viruses between Taiwan and nearby places.
Methods:
In this study, 17 specimens were identified or isolated from vector insects, and ruminant fetuses collected from 1992 to 2015 were sequenced and analysed.
Results:
Sequence analyses revealed all Taiwanese AKAVs belonged to genogroup Ia but diverged into two clusters in the phylogenetic trees, implying that at least two invasive events of AKAV may have occurred in Taiwan.
Conclusions:
The two clusters of AKAVs could still be identified in Taiwan in 2015, and a reassortment event was observed, indicating that the two clusters of AKAVs are already endemic in Taiwan.
