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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Annulation strategies for diverse heterocycles via the reductive transformation of 2-nitrostyrenes
Hari Datta Khanal1, Muthuraja Perumal1, Yong Rok Lee1
1School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea. yrlee@yu.ac.kr.
Abstract:
Reduction of the stable nitro group is a fundamental and widely used transformation for the construction of complex and functionalized heterocyclic architectures. The unfolding of the reactivity of the nitro group in the 2-nitrostyrene moiety not only triggers the formation of carbon-nitrogen bonds, but also offers the opportunity for annulation and heteroannulation, thereby providing a cascade process for the synthesis of highly conjugated natural and unnatural molecules. In this review, we comprehensively discuss the use of 2-nitrostyrene motifs in the synthesis of various N-heterocycles. We offer readers an overview of the synthetic achievements achieved to date, highlighting their important features, reactivities, and mechanisms.
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