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Lipid profile abnormalities associated with endocrine disorders.

Ewelina Szczepanek-Parulska1, Jan Sokolowski2, Dominika Dmowska2

  • 1Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland. ewelinaparulska@gmail.com.

Endokrynologia Polska
|August 16, 2022
PubMed
Summary
This summary is machine-generated.

Endocrine disorders frequently cause secondary dyslipidaemias, impacting lipid profiles. Early screening and treatment of these conditions, like hypothyroidism, are crucial for managing cardiovascular risk and improving patient health.

Keywords:
Cushing’s diseaseacromegalydyslipidaemiaendocrine diseaseshyperthyroidismhypothyroidism

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Secondary dyslipidaemias affect nearly 30% of patients with abnormal lipid profiles.
  • Endocrine disorders are a primary cause of secondary dyslipidaemia, affecting various glands like the thyroid, pituitary, adrenals, and gonads.
  • Hypothyroidism is the most prevalent endocrinopathy linked to dyslipidaemia.

Approach:

  • This review examines lipid profile alterations in endocrinopathies.
  • It details changes in standard lipid parameters: total cholesterol, LDL-C, HDL-C, and triglycerides.
  • The review also assesses the impact of endocrine disorders on emerging cardiovascular markers: apolipoprotein B, apolipoprotein A1, and lipoprotein(a).

Key Points:

  • Most endocrinopathies adversely affect lipid profiles.
  • Hyperthyroidism is an exception, potentially lowering total cholesterol, LDL-C, and triglycerides.
  • Screening for endocrine disorders is vital in diagnosing secondary dyslipidaemia.

Conclusions:

  • Early detection and treatment of endocrinopathies significantly improve patient health and cardiovascular risk.
  • Addressing hormonal imbalances can normalize lipid profiles, sometimes reducing the need for lipid-lowering therapy.
  • Comprehensive management of endocrine disorders is key to modifying cardiovascular risk and optimizing lipid profiles.