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Updated: Sep 1, 2025

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
Endometrial gland specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent
Jennifer Pearson-Farr1, Gabrielle Wheway2, Maaike Sybil Jongen3
1J Pearson-Farr, Human Development and Health, University of Southampton Faculty of Medicine, Southampton, SO16 6YD, United Kingdom of Great Britain and Northern Ireland.
Abstract:
Endometrial glands are essential for fertility, consisting of ciliated and secretory cells that facilitate a suitable uterine environment for embryo implantation. This study sought to determine whether an endometrial gland specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss. Our data provide a comprehensive catalogue of cilia and PAEP gene isoforms and relative exon usage in endometrial glands. We report a previously unannotated endometrial gland cilia transcript GALNT11 and its susceptibility to exon skipping. Key endometrial receptivity gene transcripts are also reported to change in endometrial glands of women with recurrent pregnancy loss. The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine.
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