Related Experiment Video
Updated: Aug 19, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
Published on: December 9, 2010
Reactive hyperemia in cutaneous tissue in generalized scleroderma
Abstract:
Reactive hyperemia following ischemia in cutaneous tissue of human fingers was studied in 6 normal persons and 9 patients suffering from generalized scleroderma. Ischemia lasting 6 or 12 min was induced by inflating a cuff placed around the proximal phalanx to 300 mm Hg. Blood flow was measured by the local atraumatic 133Xenon wash-out technique. The following parameters were calculated: (1) Maximum blood flow was calculated from the steepest part of the wash-out curve following release of the cuff. (2) Excess cumulative blood flow, i.e., the integrated blood flow from release of cuff until preischemic blood flow values were obtained, minus preischemic blood flow times duration of ischemia. (3) Repayment, i.e., excess cumulative blood flow in percent of preischemic blood flow times duration of ischemia. Maximum blood flow, excess cumulative blood flow and repayment was decreased in the patients compared to normals. This might be due to structural changes of the blood vessel walls and/or functional changes of the vascular smooth muscle cells in scleroderma.
Related Concept Videos
Vascular Spasm
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Rheumatic Heart Disease I: Introduction
Acute Inflammation III: Local and Systemic Effects
Chronic Inflammation: Introduction

