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Updated: Sep 1, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Understanding and Circumventing the Requirement for Native Thioester Substrates for α-Oxoamine Synthase Reactions

Sarah E Ackenhusen, Ye Wang, Stephanie W Chun

    ACS Chemical Biology
    |August 16, 2022
    PubMed
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    Researchers developed an economical method for using essential enzyme cofactors, like coenzyme A (CoA), in biocatalysis. This approach enables practical applications of CoA-dependent enzymes for preparative-scale synthesis without expensive substrates.

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