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Dynamic Catalysis Guided by Nucleic Acid Networks and DNA Nanostructures.

Yu Ouyang1, Pu Zhang1, Itamar Willner1

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This study introduces dynamic nucleic acid-enzyme and DNA nanostructures for controlled biocatalysis. These systems enable switchable catalytic cascades and model natural out-of-equilibrium transformations.

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Area of Science:

  • Biochemistry and Molecular Biology
  • Nanotechnology
  • Synthetic Biology

Background:

  • Enzymes and DNAzymes are crucial catalysts.
  • Controlling enzyme activity dynamically is challenging.
  • Supramolecular assemblies offer platforms for complex functions.

Purpose of the Study:

  • To develop novel nucleic acid-based systems for dynamic biocatalysis.
  • To create switchable catalytic cascades using enzymes and DNA nanostructures.
  • To model out-of-equilibrium biological processes.

Main Methods:

  • Conjugating enzymes to nucleic acid networks.
  • Engineering supramolecular DNA nanostructures with catalytic modules.
  • Utilizing DNA origami for programmed enzyme positioning.
  • Designing photo-switchable DNA nanomachines.

Main Results:

  • Demonstrated dynamically switched biocatalytic cascades via triggered reconfiguration.
  • Showcased feedback-driven dynamic biocatalysis by coupling networks.
  • Developed dissipative, transient biocatalytic cascades.
  • Engineered switchable DNAzymes and enzyme cascades using DNA nanostructures.
  • Achieved photo-induced ON/OFF control of DNAzyme activity.

Conclusions:

  • Nucleic acid-enzyme conjugates and DNA nanostructures are versatile platforms for dynamic catalysis.
  • These systems provide models for natural out-of-equilibrium transformations.
  • Future applications lie in advanced biocatalysis and synthetic biology.