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Updated: Sep 1, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Sleep disorder as a clinical risk factor of major depression: associated with cognitive impairment
Ru Feng Chen1, Yuan Cai1, Zhen Hua Zhu1
1Research Center of Biological Psychiatry, Suzhou Guangji Hospital, School of Basic Medicine and Biological Sciences, Suzhou Medical College of Soochow University, Suzhou 215137, Jiangsu Province, PR China.
Background:
This research aims explored the sleep disorder (SD) role in major depressive disorder (MDD), and the SD influencing their cognition.
Methods:
372 MDD patients and 457 healthy controls (HCs) were enrolled.
Results:
Patients increased a 38.88 times SD risk compared with HCs. In patients, visuospatial/constructional score was lower in SD than non-SD, and PSQI score was negatively associated with visuospatial/constructional score of SD. In SD and non-SD, RBANS scores were lower in MDD than HCs, excepted for visuospatial/constructional in non-SD.
Conclusion:
The SD as a MDD risk factor, has more serious visuospatial/constructional impairment alleviated via improving sleep/depression in patients.
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