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Targeted therapy for breast cancer: An overview of drug classes and outcomes
Aaron T Jacobs1, Diana Martinez Castaneda-Cruz1, Mark M Rose1
1California University of Science and Medicine, 1501 Violet Street, Colton, CA 92324, United States.
Abstract:
The last 25 years have seen significant growth in new therapeutic options for breast cancer, termed targeted therapies based on their ability to block specific pathways known to drive breast tumor growth and survival. Introduction of these drugs has been made possible through advances in the understanding of breast cancer biology. While the promise of targeted therapy for breast cancer has been clear for some time, the experience of the clinical use of multiple drugs and drug classes allows us to now present a summary and perspective as to the success and impact of this endeavor. Here we will review breast cancer targeted therapeutics in clinical use. We will provide the rationale for their indications and summarize clinical data in patients with different breast cancer subtypes, their impact on breast cancer progression and survival and their major adverse effects. The focus of this review will be on the development that has occurred within classes of targeted therapies and subsequent impact on breast cancer patient outcomes. We will conclude with a perspective on the role of targeted therapy in breast cancer treatment and highlight future areas of development.
Insights
Targeted therapies have revolutionized breast cancer treatment over the past 25 years by blocking specific tumor growth pathways. This review summarizes their clinical success, impact on patient outcomes, and future directions in breast cancer therapy.
Area of Science:
- Oncology
- Pharmacology
- Genomics
Background:
- Significant advancements in understanding breast cancer biology have enabled the development of targeted therapies.
- Targeted therapies offer a promising approach by inhibiting specific pathways crucial for tumor growth and survival.
Purpose of the Study:
- To review currently used targeted therapeutics for breast cancer.
- To summarize clinical data, indications, and impact on patient outcomes across different breast cancer subtypes.
- To provide a perspective on the role and future development of targeted therapies in breast cancer treatment.
Main Methods:
- Review of clinical data for targeted therapies in breast cancer.
- Analysis of drug development within targeted therapy classes.
- Evaluation of impact on breast cancer progression, survival, and adverse effects.
Main Results:
- Targeted therapies have shown significant success in improving breast cancer progression and survival rates.
- Clinical data demonstrate efficacy across various breast cancer subtypes.
- Major adverse effects associated with targeted therapies have been identified.
Conclusions:
- Targeted therapy has become a cornerstone in breast cancer treatment, significantly impacting patient outcomes.
- Continued development within targeted therapy classes holds promise for further improving breast cancer care.
- Future research should focus on novel targeted agents and personalized treatment strategies.
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