Jove
Visualize
Contact Us

Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

7.1K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
7.1K
Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

5.1K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iron overload disrupts bone homeostasis via TfR1-dependent ferroptosis and cGAS/STING-driven pyroptosis in pyogenic spondylitis.

Frontiers in immunology·2026
Same author

Miniaturized wireless bioelectronics for electrically driven biohybrid robots.

Scientific reports·2026
Same author

Compressive stress induces cartilage endplate degeneration through the Piezo1/YAP-TEAD/NLRP3 axis.

Life sciences·2026
Same author

A localized vertebral infection model of pyogenic spondylitis induced by <i>Staphylococcus aureus</i> in rats.

Frontiers in medicine·2025
Same author

360° size-adjustable microelectrode array system for electrophysiological monitoring of cerebral organoids.

Frontiers in bioengineering and biotechnology·2025
Same author

Spontaneous differentiation of human induced pluripotent stem cells to odorant-responsive olfactory sensory neurons.

Biochemical and biophysical research communications·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 1, 2025

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy
10:40

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

Published on: June 28, 2016

7.6K

Ultra-high-resolution quanta image sensor with reliable photon-number-resolving and high dynamic range capabilities.

Jiaju Ma1, Dexue Zhang2, Dakota Robledo2

  • 1Gigajot Technology, Inc., Pasadena, CA, USA. jiaju.ma@gigajot.tech.

Scientific Reports
|August 16, 2022
PubMed
Summary

This study introduces a 163-megapixel quanta image sensor (QIS) offering unparalleled low-light and high dynamic range (HDR) imaging. It achieves reliable photon-number resolving and HDR in a single device, setting a new standard for image sensor technology.

More Related Videos

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

24.0K
High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

1.4K

Related Experiment Videos

Last Updated: Sep 1, 2025

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy
10:40

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

Published on: June 28, 2016

7.6K
A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

24.0K
High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

1.4K

Area of Science:

  • Solid-state imaging technology
  • Photonics and optical sensors
  • Advanced semiconductor devices

Background:

  • Traditional charge-coupled devices (CCD) and complementary metal-oxide-semiconductor (CMOS) sensors have limitations in low-light and high dynamic range (HDR) imaging.
  • The quanta image sensor (QIS) concept, proposed in 2005, aims to overcome these limitations with photon-number-resolving capabilities.
  • Achieving ultra-high pixel resolution alongside reliable photon-number resolving and HDR has been a significant challenge in image sensor development.

Purpose of the Study:

  • To present a novel 163-megapixel quanta image sensor (QIS) capable of both reliable photon-number resolving and high dynamic range (HDR) imaging.
  • To demonstrate the highest pixel resolution reported to date for low-noise image sensors with photon-number-resolving capability.
  • To detail the design, operating principles, and experimental validation of this advanced QIS device.

Main Methods:

  • Fabrication of a 163-megapixel QIS using a standard, state-of-the-art CMOS process.
  • Implementation of 2-layer wafer stacking and backside illumination techniques.
  • Characterization of photon-number resolving capability and dynamic range performance.

Main Results:

  • Demonstrated reliable photon-number resolving with an average read noise of 0.35 e- rms at room temperature.
  • Achieved a dynamic range of 95 dB, attributed to the extremely low noise floor and extended full-well capacity (20k e-).
  • The developed QIS exhibits the highest pixel resolution among low-noise, photon-number-resolving image sensors.

Conclusions:

  • The presented 163 MP QIS successfully integrates reliable photon-number resolving and high dynamic range imaging.
  • This device offers industry-leading low-light imaging performance and sets a new benchmark for pixel resolution in its class.
  • The findings pave the way for next-generation image sensors with superior imaging capabilities over existing CCD and CMOS technologies.