Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transduction01:16

Transduction

86
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
86
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

2.8K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
2.8K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

70.4K
Overview
70.4K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

6.6K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adipocyte caspase-8 but not RIPK3 promotes adiposity.

Cell death discovery·2026
Same author

Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

BET inhibition curbs macrophage inflammation, lipid accumulation, and atherogenesis by disrupting the YAP/TAZ-BRD4 axis.

Journal of leukocyte biology·2026
Same author

The case for space as a model of accelerated aging.

Nature aging·2026
Same author

Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages.

Science advances·2026
Same author

Simulated Microgravity Recapitulates Aspects of Biological Aging in Humans.

bioRxiv : the preprint server for biology·2026
Same journal

A guide to CAR T cell therapies: development, current status and future prospects.

Nature reviews. Immunology·2026
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026
Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026
Same journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
See all related articles

Related Experiment Video

Updated: Sep 1, 2025

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells
06:53

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

Published on: March 20, 2021

2.8K

Tuning immunity through tissue mechanotransduction.

Huixun Du1,2, Juliet M Bartleson1, Sergei Butenko3,4,5

  • 1Buck Institute for Research on Aging, Novato, CA, USA.

Nature Reviews. Immunology
|August 16, 2022
PubMed
Summary
This summary is machine-generated.

Tissue mechanics significantly influence immune cell function through mechanotransduction. Understanding these mechanical signals is crucial for regulating immune responses in health and disease.

More Related Videos

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

1.3K
Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.5K

Related Experiment Videos

Last Updated: Sep 1, 2025

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells
06:53

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

Published on: March 20, 2021

2.8K
A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

1.3K
Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.5K

Area of Science:

  • Immunology
  • Biophysics
  • Cell Biology

Background:

  • Immune responses are regulated by the tissue microenvironment.
  • Mechanical cues from tissues, extracellular matrix, and cells impact immune cell function.
  • Changes in tissue biophysical properties alter mechanical signals in disease, inflammation, and aging.

Purpose of the Study:

  • To review the emerging field of mechanoimmunology.
  • To focus on how mechanical cues regulate immune cell behaviors.
  • To highlight the role of tissue mechanics in initiating, propagating, and resolving immune responses.

Main Methods:

  • Review of existing literature on mechanoimmunology.
  • Discussion of mechanotransduction pathways in immune cells.
  • Analysis of how tissue mechanics influence immune cell functions.

Main Results:

  • Mechanical cues are converted into biochemical signals via mechanotransduction.
  • Mechanotransduction pathways affect immune cell activation, cytokine production, metabolism, proliferation, and trafficking.
  • Altered tissue mechanics can act as a 'danger signal' to the immune system.

Conclusions:

  • Tissue mechanics provide a dynamic layer of immune regulation.
  • Understanding mechanoimmunology is key to comprehending immune responses.
  • Mechanical forces are integral to immune cell behavior and function.