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Diagnostic applications of microsphere-based flow cytometry: A review
Adélia Marques de Figueiredo1, Juliane Corrêa Glória1, Yury Oliveira Chaves2,3
1Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Amazonas (UFAM), Manaus 69067-005, Brazil.
Experimental Biology and Medicine (Maywood, N.J.)
|August 17, 2022
Summary
Microsphere-based flow cytometry offers sensitive detection of disease biomarkers. This versatile technology aids in early diagnosis, epidemiological surveillance, and developing new diagnostic methods for various conditions.
Area of Science:
- Biotechnology
- Clinical Diagnostics
- Immunology
Background:
- Microsphere-based flow cytometry is an emerging technology for sensitive detection.
- It is valuable for analyzing antigens, antibodies, and nucleic acids.
Purpose of the Study:
- To review studies applying flow cytometry for infectious disease investigation.
- To highlight its role in epidemiological surveillance, vaccine development, and early cancer diagnosis.
Main Methods:
- Analysis of existing studies on microsphere-based flow cytometry applications.
- Focus on research involving biomarker detection for various diseases.
Main Results:
- Flow cytometry enables simultaneous detection of multiple biomarkers.
- The technique offers high sensitivity, detecting molecules at low concentrations with minimal sample volume.
- It provides accurate, non-invasive diagnostic approaches.
Conclusions:
- Microsphere-based flow cytometry is a versatile and promising technique.
- It can be a fundamental tool for developing novel diagnostic methods for numerous diseases.

