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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
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CYTOMEGALOVIRUS INFECTION AND CONGENITAL HYPOTHYROIDISM: POSSIBLE ASSOCIATION.

G Tuli1,2, J Munarin1,2, F Mignone2,3

  • 1Regina Margherita Children's Hospital of Turin, Department of Pediatric Endocrinology, Turin, Italy.

Acta Endocrinologica (Bucharest, Romania : 2005)
|August 17, 2022
PubMed
Summary

Congenital hypothyroidism (CH) is linked to congenital cytomegalovirus (cCMV) infection. Early detection and considering cCMV are crucial for newborns with CH, especially if treatment is ineffective.

Keywords:
Congenital Cytomegalovirus infectionCongenital hypothyroidismassociationneonatal

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Area of Science:

  • Endocrinology
  • Virology
  • Neonatology

Background:

  • Congenital hypothyroidism (CH) is a common endocrine disorder.
  • CH is frequently associated with congenital anomalies.
  • Congenital cytomegalovirus (cCMV) infection shares similar associated anomalies.

Observation:

  • Two cases of newborns with both CH and cCMV infection are presented.
  • Case 1: Thyroid agenesis and persistent hypotonia despite L-thyroxine treatment led to cCMV diagnosis.
  • Case 2: Thyroid dyshormonogenesis diagnosed with maternal CMV seroconversion in the first trimester.

Findings:

  • CH incidence in Piedmont, Italy (2014-2019) increased to 1:1090.
  • Higher incidence of cCMV infection observed in infants with CH (12/1000) compared to those without (5-7/1000).
  • This study reports the first data on the association between cCMV infection and CH.

Implications:

  • Alerting caregivers to maternal seroconversion can help prevent fetal hypothyroidism.
  • Consider cCMV infection in newborns with CH whose condition doesn't improve with L-thyroxine treatment.
  • Highlights the importance of investigating cCMV in CH cases with poor treatment response.