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EMPTY SELLA IN A PATIENT WITH CLINICAL AND BIOCHEMICAL DIAGNOSIS OF ACROMEGALY
N Bestepe1, C Aydin2, A A Tam2
1Ankara City Hospital, Dept. of Endocrinology and Metabolism, Ankara, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|August 17, 2022
Summary
This case study highlights a patient with acromegaly and empty sella (ES). Treatment with octreotide effectively reduced growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels, suggesting a potential link between these conditions.
Area of Science:
- Endocrinology
- Neuroimaging
- Oncology
Background:
- Acromegaly results from excess growth hormone (GH) and insulin-like growth factor-1 (IGF-1).
- Empty sella (ES) is characterized by cerebrospinal fluid filling the sella turcica.
- This report details a patient with acromegaly and ES.
Observation:
- A 73-year-old male presented with acromegalic features and an empty sella on pituitary MRI.
- Elevated serum GH and IGF-1 levels confirmed active acromegaly.
- Imaging ruled out ectopic GH secretion and GHRH was within normal limits.
Findings:
- The patient received long-acting octreotide treatment for acromegaly.
- Six months post-treatment, significant reductions in GH and IGF-1 levels were observed.
- The case suggests primary empty sella as a potential factor in this patient's presentation.
Implications:
- This case highlights the importance of considering pituitary imaging in acromegaly patients.
- Effective management of acromegaly can be achieved with somatostatin analogs like octreotide.
- Further research is needed to elucidate the relationship between acromegaly and empty sella.
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