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Oxygen diffusion in chronic venous ulceration.

H H Moosa, V Falanga, D L Steed

    The Journal of Cardiovascular Surgery
    |July 1, 1987
    PubMed
    Summary
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    A fibrin-induced oxygen diffusion barrier around capillaries in venous ulcers significantly lowers tissue oxygen levels. This barrier is confirmed by transcutaneous oxygen measurements, suggesting a key factor in venous ulcer development.

    Area of Science:

    • Vascular Biology
    • Dermatology
    • Wound Healing

    Background:

    • Venous hypertension is linked to capillary changes and potential oxygen diffusion barriers.
    • Fibrin deposition around capillaries may impede oxygen supply to tissues.

    Purpose of the Study:

    • To investigate the existence and impact of a local oxygen diffusion barrier in patients with venous ulcers.
    • To quantify transcutaneous oxygen levels in skin adjacent to venous ulcers.

    Main Methods:

    • Employed the transcutaneous oxygen (TcPO2) monitor (TCM204 Radiometer) in 18 patients with venous ulcers.
    • Measured TcPO2 on lower limbs adjacent to ulcers, chest, and foot.
    • Assessed TcPO2 response to 100% oxygen inhalation.

    Main Results:

    Related Experiment Videos

    • Markedly decreased TcPO2 values (10 +/- 2 mmHg) were observed adjacent to venous ulcers compared to chest (64 +/- 2 mmHg) and foot (43 +/- 2 mmHg).
    • Oxygen inhalation significantly increased TcPO2 around ulcers in 17 of 18 patients (61 +/- 13 mmHg).

    Conclusions:

    • The study supports the presence of a localized pathologic barrier to oxygen diffusion in venous ulceration.
    • This diffusion barrier likely contributes to the pathophysiology of venous ulcer development.