Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Mutations00:36

Viral Mutations

32.8K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.8K
Predicting Products: Substitution vs. Elimination02:52

Predicting Products: Substitution vs. Elimination

12.0K
When a nucleophile and an alkyl halide react, nucleophilic substitution and β-elimination reactions compete to generate products.
The following factors can influence the mechanisms competing against each other:
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative management of anticoagulation.

The British journal of surgery·2026
Same author

Accelerated Porosity Screening Using a Multichannel Colorimetric Array.

Angewandte Chemie (International ed. in English)·2025
Same author

Modelling immunity gaps to quantify infection resurgences.

Royal Society open science·2025
Same author

Modelling the initial stages of biocontrol of the invasive herb <i>Tradescantia fluminensis</i> by beetles.

Royal Society open science·2025
Same author

A mathematically robust model of exotic pine invasions.

Mathematical biosciences·2025
Same author

Incorporating Behavioral Science in Medication Adherence Communication: A Randomized Clinical Trial.

JAMA network open·2025

Related Experiment Video

Updated: Sep 1, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.3K

Predicting elimination of evolving virus variants.

Elliott Hughes1,2, Rachelle Binny3,2, Shaun Hendy2,4

  • 1School of Mathematics and Statistics, University of Canterbury, Christchurch 8140, New Zealand.

Mathematical Medicine and Biology : a Journal of the IMA
|August 17, 2022
PubMed
Summary
This summary is machine-generated.

Rapidly updating vaccines against new SARS-CoV-2 variants is crucial. Non-pharmaceutical interventions remain vital during vaccine delivery, and tracking new variants helps predict virus elimination.

Keywords:
branching processselection pressurevirus evolutionary tree

More Related Videos

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

11.9K
Reverse Genetics to Engineer Positive-Sense RNA Virus Variants
15:49

Reverse Genetics to Engineer Positive-Sense RNA Virus Variants

Published on: June 9, 2022

1.5K

Related Experiment Videos

Last Updated: Sep 1, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.3K
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

11.9K
Reverse Genetics to Engineer Positive-Sense RNA Virus Variants
15:49

Reverse Genetics to Engineer Positive-Sense RNA Virus Variants

Published on: June 9, 2022

1.5K

Area of Science:

  • Epidemiology
  • Virology
  • Mathematical Modeling

Background:

  • The global spread of SARS-CoV-2 has led to the emergence of new variants.
  • Existing vaccines show reduced effectiveness against novel strains, necessitating adaptive strategies.
  • Widespread unvaccinated populations globally remain vulnerable to evolving viral threats.

Purpose of the Study:

  • To model the spread of novel viruses, incorporating variant evolution and vaccine effectiveness.
  • To evaluate the impact of vaccine update speed and non-pharmaceutical interventions (NPIs) on disease containment.
  • To identify observable metrics that correlate with the probability of virus elimination.

Main Methods:

  • Development of a simple mathematical model for disease transmission dynamics.
  • Inclusion of parameters for viral mutation rates, variant emergence, and strain-specific vaccine efficacy.
  • Simulation of different vaccine update strategies and NPI implementation scenarios.

Main Results:

  • Rapid vaccine updates targeting new SARS-CoV-2 strains are significantly more effective than delayed updates.
  • Non-pharmaceutical interventions are critical for controlling spread during the vaccine rollout period.
  • The number of observed new variants strongly correlates with the probability of virus elimination, serving as a useful proxy for difficult-to-measure input parameters.

Conclusions:

  • Adaptive vaccination strategies, including rapid updates, are essential for managing evolving viral threats like SARS-CoV-2.
  • A combination of timely vaccination and NPIs is necessary for effective pandemic control.
  • Monitoring the emergence of new variants provides valuable insights into the potential for virus eradication.