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C-Reactive Protein to Albumin Ratio in Patients with Prediabetes and Diabetes Mellitus: HbA1c and Inflammation

Muhammed E Demirkol, Murat Alisik, Ozgur M Yis

    Clinical Laboratory
    |August 17, 2022
    PubMed

    Insights

    The C-reactive protein to albumin ratio (CAR) is elevated in prediabetes and diabetes mellitus (DM), particularly in uncontrolled DM. This liver-related inflammatory marker shows potential for clinical application in managing these conditions.

    Area of Science:

    • Endocrinology
    • Clinical Chemistry
    • Inflammation Research

    Background:

    • Inflammation plays a key role in diabetes mellitus (DM) pathogenesis and complications.
    • Assessing inflammatory markers is crucial for understanding and managing DM and prediabetes.
    • The C-reactive protein to albumin ratio (CAR) is a potential indicator of inflammation.

    Purpose of the Study:

    • To compare C-reactive protein to albumin ratio (CAR) values across controlled DM, uncontrolled DM, prediabetes, and healthy individuals.
    • To evaluate CAR as an inflammatory marker in different glycemic states.
    • To analyze the relationship between HbA1c levels and inflammatory markers.

    Main Methods:

    • Retrospective analysis of 6,993 DM patients, 770 prediabetes patients, and 1,340 healthy individuals.
    • Classification of DM patients into controlled (HbA1c < 6.5%) and uncontrolled (HbA1c ≥ 6.5%) groups.
    • Measurement and comparison of C-reactive protein (CRP) and albumin levels to calculate CAR.

    Main Results:

    • Significantly higher CRP and CAR levels were observed in DM and prediabetes groups compared to controls.
    • Albumin levels were significantly lower in the DM group versus prediabetes and control groups.
    • Uncontrolled DM showed significantly higher CRP and CAR, and lower albumin levels compared to controlled DM and controls.

    Conclusions:

    • CAR, a liver-related inflammatory marker, is a potential biomarker for inflammation in prediabetes and DM.
    • CAR may be a useful tool for monitoring inflammation in patients with diabetes.
    • Further prospective studies are recommended to confirm the utility of CAR in DM and prediabetes.
    Abstract

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