Related Experiment Video
Updated: Sep 1, 2025
Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
Pseudoleukocytopenia: a Case Report
Background:
Hematology analyzers provide quick and accurate results in most situations. However, spurious results related to the parameters from the complete blood count (CBC) may be observed in several instances. False increases in WBC count can occur for many reasons, including erythroblasts, insufficiently lysed red blood cells (RBC), platelet aggregates, lipids, and cryoglobulins. However, cases of pseudoleukocytopenia due to plasma related factors are rare.
Methods And Results:
Here, we report a case of pseudoleukocytopenia in CBC test. It was identified by the peripheral blood smears and different scatter plots of WNR and WDF channel. The interference from plasma was con-firmed by simulating the state of blood in the WBC channel and plasma exchange.
Conclusions:
It was confirmed that the interference of pseudoleukocytopenia was from the plasma. This may be due to the high amount of albumin and other therapeutic drug reactions. Observation of peripheral blood smears and scatter plots can identify this interference.
Related Concept Videos
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
01:27Acute Pyelonephritis I: Introduction
01:28Acute Pyelonephritis II: Diagnostic Studies and Management