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Disorders of Leukocytes01:27

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Assessment of the Metabolic Profile of Primary Leukemia Cells
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Pseudoleukocytopenia: a Case Report.

Xiang Qian, Kankan Su, Lixia Zhang

    Clinical Laboratory
    |August 17, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Pseudoleukocytopenia, a rare condition causing falsely low white blood cell counts, was identified in a complete blood count test. Plasma interference, potentially due to high albumin or drug reactions, was confirmed.

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    Area of Science:

    • Clinical Hematology
    • Laboratory Medicine
    • Diagnostic Accuracy

    Background:

    • Hematology analyzers are crucial for rapid and accurate complete blood count (CBC) testing.
    • Spurious results can occur due to various factors, including erythroblasts, RBC lysis issues, platelet aggregates, lipids, and cryoglobulins.
    • Pseudoleukocytopenia, a false decrease in white blood cell (WBC) count, is infrequently associated with plasma-related interferences.

    Observation:

    • A case of pseudoleukocytopenia was identified during routine CBC analysis.
    • Peripheral blood smears and specific analyzer scatter plots (WNR and WDF channels) were instrumental in initial detection.
    • Experimental manipulation, including simulating WBC channel conditions and plasma exchange, confirmed plasma as the source of interference.

    Findings:

    • The study confirmed plasma interference as the cause of pseudoleukocytopenia.
    • Elevated albumin levels and reactions to therapeutic drugs were identified as potential contributing factors.
    • The interference was successfully identified through careful examination of peripheral blood smears and analyzer scatter plots.

    Implications:

    • This case highlights the importance of considering plasma-related factors in diagnosing pseudoleukocytopenia.
    • Routine microscopic examination and flow cytometry scatter plot analysis are vital for identifying such interferences.
    • Understanding these rare interferences improves the reliability of CBC results in clinical practice.