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Clinical Significance of miRNA-145 and -126 in Chronic Obstructive Pulmonary Disease with Pulmonary Embolism

Asmaa Nafady, Alaa Rashad, Hanaa Nafady-Hego

    Clinical Laboratory
    |August 17, 2022
    PubMed
    Abstract

    Insights

    In chronic obstructive pulmonary disease (COPD) patients, lower levels of microRNA-145 and higher levels of microRNA-126 are linked to pulmonary embolism (PE). Further research is needed to understand their role in thrombosis.

    Area of Science:

    • Pulmonary Medicine
    • Molecular Biology
    • Genetics

    Background:

    • Pulmonary embolism (PE) exacerbates chronic obstructive pulmonary disease (COPD) due to hypercoagulability.
    • MicroRNAs (miRNAs) are increasingly recognized for their role in PE development within COPD patients.

    Purpose of the Study:

    • To quantify and compare the expression levels of microRNA-145 and microRNA-126 in COPD patients with and without PE.
    • To investigate the correlation of these miRNAs with clinical parameters such as FEV1/FVC and D-dimer.

    Main Methods:

    • Quantitative real-time PCR was used to measure miRNA-145 and miRNA-126 levels.
    • Expression data were analyzed from 250 COPD patients with PE and 300 COPD patients without PE.

    Main Results:

    • miRNA-145 expression was significantly downregulated in COPD patients with PE compared to those without PE.
    • miRNA-126 expression was significantly upregulated in COPD patients with PE compared to those without PE.
    • miRNA-145 showed a positive correlation with FEV1/FVC and a negative correlation with D-dimer, while miRNA-126 showed the inverse correlations.

    Conclusions:

    • Reduced miRNA-145 and elevated miRNA-126 levels are associated with a worse prognosis of PE in COPD patients.
    • These findings suggest a potential role for these miRNAs in the pathogenesis of thrombosis in COPD.
    • Further extensive research is required to elucidate the precise mechanisms involving these miRNAs in COPD-related thrombosis.

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