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Published on: September 20, 2016
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Aggressive histological component in subsolid lung adenocarcinoma: priority for resection without delay.
Masaya Yotsukura1, Kazuo Nakagawa1, Chihiro Takemura1
1Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Japanese Journal of Clinical Oncology
|August 17, 2022
Summary
Predictors for aggressive components in lung adenocarcinoma with ground glass opacity were identified. A high consolidation/tumour ratio, elevated PET SUVmax, and significant smoking history predict aggressive features, aiding prognosis screening.
Area of Science:
- Pulmonology
- Oncology
- Radiology
Background:
- Lung adenocarcinoma with ground glass opacity (GGO) presents a diagnostic challenge.
- Identifying aggressive components is crucial for predicting prognosis in early-stage lung cancer.
Purpose of the Study:
- To explore predictors of histological aggressive components in GGO-containing lung adenocarcinoma.
- To identify factors associated with a poor prognosis in early-stage adenocarcinoma.
Main Methods:
- Retrospective analysis of 501 patients with GGO-containing adenocarcinoma (≤2 cm) undergoing resection.
- Multivariable analysis to identify predictors of histological aggressive components.
Main Results:
- Lymphovascular invasion and micropapillary/solid patterns were identified as aggressive components.
- Predictors for aggressive components included consolidation/tumour ratio > 0.5, SUVmax ≥ 1.5, and smoking index > 20 pack-years.
- 98% of cases lacking these factors did not show aggressive components.
Conclusions:
- Approximately 7% of small GGO-containing adenocarcinomas harbor aggressive components.
- Consolidation/tumour ratio, SUVmax, and smoking index are significant predictors.
- These predictors can aid in screening high-risk patients for timely resection.
