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Wireless Lateral Flow Device for Biosensing.

Jie Li1, Weize Yuan1, Shao-Xiong Lennon Luo1

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Journal of the American Chemical Society
|August 17, 2022
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Summary
This summary is machine-generated.

This study introduces a wireless lateral flow device that uses radio frequency identification (RFID) to detect enzyme activity. The biosensor converts oxidase reactions into measurable changes in RFID resonance for rapid, portable biological signal detection.

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Area of Science:

  • Biosensors and bioelectronics
  • Materials science
  • Analytical chemistry

Background:

  • Biosensing often relies on enzyme-catalyzed reactions, requiring efficient detection methods.
  • Existing methods may lack portability, speed, or cost-effectiveness for widespread application.

Purpose of the Study:

  • To develop a wireless lateral flow device for quantitative biological signal detection.
  • To integrate radio frequency identification (RFID) circuitry with enzyme-based detection.
  • To create a low-cost, rapid, and portable biosensing platform.

Main Methods:

  • Developed a wireless lateral flow device utilizing polypyrrole (pPy) core-shell colloidal particles.
  • Bioconjugated pPy particles with glucose oxidase or pyruvate oxidase for streptavidin-biotin recognition.
  • Utilized polyoxometalate-catalyzed oxidative doping of pPy by H2O2 generated from oxidase reactions.
  • Integrated the pPy chemiresistive band into an RFID circuit to convert resistivity changes to RF resonance shifts.

Main Results:

  • Achieved conductivity enhancements exceeding 7·10^5% in the pPy bands due to oxidase reactions.
  • Demonstrated quantitative detection of glucose as low as 0.6 mM within 30 minutes.
  • Showcased significant responses for both glucose and pyruvate detection.
  • Successfully converted enzymatic H2O2 production into measurable changes in RFID resonance.

Conclusions:

  • The developed oxidase enzymes/pPy transduction system provides a robust platform for lateral flow devices.
  • This technology enables a new family of portable, low-cost biosensors for detecting and quantifying biological targets.
  • The wireless RFID integration offers a promising approach for point-of-care diagnostics and field testing.