Related Experiment Video
Updated: Sep 1, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Gross necropsy, histopathology, and ancillary test results from neonatal beef calves submitted to a veterinary
Luis A Rivero1, Shuping Zhang2,3, Loren G Schultz1
11Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO.
Objective:
The objective of this study was to evaluate the prevalence of abnormal findings in gross necropsy, histopathology, and ancillary test results from neonatal beef calves submitted to a veterinary diagnostic laboratory.
Samples:
This retrospective clinical case study was conducted by reviewing necropsy reports submitted between 2015 to 2020. Case inclusion criteria were animals had to be a bovine, 2 to 21 days of age, and a nondairy breed.
Procedures:
Gross necropsy, histopathology, and laboratory test results were recorded. Identified lesions and abnormal test results were categorized based on body systems and infectious agent type. Age and system affected were analyzed using a 1-way ANOVA and Bonferonni pairwise comparisons.
Results:
Overall, 1,060 reports were reviewed and 95 met the inclusion criteria. Median age of enrolled calves was 9 days (range, 2 to 21). A total of 252 lesions were identified with a median of 3 lesions/calf (range, 0 to 7) and 2 different body systems involved/calf (range, 0 to 5). The most common disorders were classified as digestive (42.1% [106/252]), respiratory (12.7% [32/252]), and multisystemic (11.1% [28/252]). With respect to age and system affected, calves with neurologic lesions were significantly younger (mean age, 5.1 days) than calves with digestive lesions (mean age 9.6 days).
Clinical Relevance:
These data suggest a high prevalence of infectious diseases, mainly digestive, respiratory and multisystemic in origin. These findings could help guide producers and veterinarians when assessing factors contributing to neonatal beef calf loss.
More Related Videos
08:27Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
12:53Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
Published on: May 19, 2018