Gamete intra-Fallopian transfer: evaluation of 100 consecutive attempts

Area of Science:

• Reproductive Medicine
• Infertility Treatment
• Assisted Reproductive Technologies

Background:

• Persistent infertility affects numerous couples worldwide.
• Gamete intra-Fallopian transfer (GIFT) is an assisted reproductive technology.
• Evaluating the efficacy of GIFT is crucial for treatment strategies.

Purpose of the Study:

• To report the outcomes of 100 gamete intra-Fallopian transfer (GIFT) procedures.
• To assess the pregnancy and live birth rates associated with GIFT.
• To evaluate the impact of combining GIFT with in-vitro fertilization (IVF) and cryopreservation.

Main Methods:

• Performed 100 GIFT procedures for persistent infertility.
• Administered GIFT by placing oocytes and spermatozoa into a healthy fallopian tube.
• Combined GIFT with in-vitro fertilization for oocyte insemination and embryo culture, with cryopreservation of excess embryos.

Main Results:

• Achieved 24 pregnancies from 100 GIFT procedures.
• Reported a 28% pregnancy rate for idiopathic infertility, 13% for male infertility, 22% for endometriosis, and 29% for antisperm antibodies.
• Successfully achieved five additional ongoing pregnancies through the transfer of frozen-thawed embryos.

Conclusions:

• Gamete intra-Fallopian transfer (GIFT) is an effective treatment for persistent infertility.
• Combining GIFT with in-vitro fertilization and embryo cryopreservation significantly enhances conception rates.
• The study demonstrates the value of a multi-faceted approach to assisted reproduction.