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Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Updated: Sep 1, 2025

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
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Contrast Enhanced Mammography in Routine Clinical Practice: Frequency and Malignancy Rates of Enhancing Otherwise

Taylor Viggiano1, Ryan Scott2, Richard Sharpe2

  • 1Mayo Clinic Alix School of Medicine, Mayo Clinic, Phoenix, AZ.

Clinical Breast Cancer
|August 17, 2022
PubMed
Summary
This summary is machine-generated.

Contrast-enhanced mammography (CEM) reveals unique enhancing findings in 4% of exams. Magnetic resonance (MR) imaging helps differentiate benign from malignant lesions, guiding patient management and potentially avoiding unnecessary biopsies.

Keywords:
Contrast enhanced mammographyContrast mammographyMR-guided biopsybreast MRbreast cancer

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Area of Science:

  • Breast Imaging
  • Radiology
  • Oncology

Background:

  • Contrast-enhanced mammography (CEM) can identify enhancing lesions not visible on standard mammograms or ultrasounds.
  • These subtraction-only findings present a diagnostic challenge in breast imaging.
  • Understanding their frequency and malignancy rates is crucial for clinical practice.

Purpose of the Study:

  • To determine the frequency of enhancing findings visible only on subtraction images in CEM.
  • To report the malignancy rates associated with these subtraction-only findings.
  • To evaluate the role of magnetic resonance (MR) imaging in characterizing these findings.

Main Methods:

  • A retrospective review of consecutive CEM examinations from December 2015 to May 2020.
  • Statistical analysis, including chi-square tests, was used to assess associations with cancer diagnosis.
  • Correlation with MR imaging and biopsy results was performed for selected cases.

Main Results:

  • Enhancing findings visible only on subtraction images were identified in 4% (100/2464) of CEM exams.
  • A subset of these findings required further evaluation with MR imaging.
  • MR-guided biopsies of suspicious subtraction-only findings revealed malignancy in 26% and high-risk lesions in 9% of cases.

Conclusions:

  • Enhancing findings on subtraction-only CEM images occur in 4% of clinical practice cases.
  • MR imaging is valuable for characterizing these findings, helping to avoid unnecessary biopsies for benign lesions.
  • MR correlation aids in guiding tissue sampling or surgical planning for suspicious findings.