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Related Concept Videos

Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Related Experiment Video

Updated: Jun 12, 2026

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter
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Recent Advances in DNA-Based Cell Surface Engineering for Biological Applications.

Lexun Li1, Shuang Liu1, Chunjuan Zhang1

  • 1Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Biology, Hunan University Changsha, Hunan, 410082, People's Republic of China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 17, 2022
PubMed
Summary

DNA nanotechnology offers advanced cell surface engineering. This review covers DNA immobilization methods, DNA nanostructures for functional surfaces, and diverse biological applications, highlighting future prospects.

Keywords:
DNA nanostructurecell manipulationcell recognitioncell surface engineeringnanotechnology

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Synthetic Biology

Background:

  • DNA's programmability and biocompatibility are advantageous for cell surface engineering.
  • Recent advancements enable reliable engineering of cell surfaces with DNA molecules and nanostructures.

Purpose of the Study:

  • To review recent progress in DNA-based cell surface engineering.
  • To explore its biological applications and future challenges.

Main Methods:

  • Immobilization of DNA molecules on cell surfaces.
  • Utilizing DNA nanostructures and dynamic DNA nanotechnology for functional cell surfaces.

Main Results:

  • Diverse DNA molecules and nanostructures expand the toolbox for cell surface engineering.
  • Novel applications arise from engineered functional cell surfaces.

Conclusions:

  • DNA-based cell surface engineering offers significant potential for biological applications.
  • Further research is needed to address challenges and explore future prospects.