Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

5.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
5.0K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

228
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
228

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early timepoint <sup>99m</sup>Tc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis.

EJNMMI research·2026
Same author

Semi-quantitative evaluation of early phase <sup>99m</sup>Tc-DPD scintigraphy in patients with suspected cardiac amyloidosis.

Annals of nuclear medicine·2026
Same author

[Initially palliative, later converted to neoadjuvant therapy in advanced, extensively mediastinal lymphogenous metastatic follicular thyroid carcinoma - a case report].

Deutsche medizinische Wochenschrift (1946)·2026
Same author

Evaluation of Gd-DOTA as a marker for myocardial blood flow using <sup>68</sup>Ga-DOTA and <sup>15</sup>O-water positron emission tomography.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2026
Same author

Prognostic parameters and detection of cardiac amyloidosis with hybrid <sup>18</sup>F-Florbetaben-PET/MRI: an exploratory observational study.

European journal of nuclear medicine and molecular imaging·2026
Same author

Nuclear cardiology - Current status of the clinical application.

Nuklearmedizin. Nuclear medicine·2026

Related Experiment Video

Updated: Sep 1, 2025

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.4K

Phantom-based acquisition time and image reconstruction parameter optimisation for oncologic FDG PET/CT examinations

Pedro Fragoso Costa1,2, Walter Jentzen1,2, Alissa Brahmer1,2

  • 1Department of Nuclear Medicine, University Hospital Essen, West German Cancer Center (WTZ), University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.

BMC Cancer
|August 17, 2022
PubMed
Summary

A threefold reduction in 18F-FDG PET acquisition time is possible using silicon-photomultiplier (SiPM)-based PET/CT systems. This allows for more comfortable patient examinations or reduced radiation exposure.

Keywords:
Acquisition timeDigital PETFDGLymphomaPositron emission tomographyProtocol optimisationSilicon-based photomultiplier

More Related Videos

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.2K
Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

5.7K

Related Experiment Videos

Last Updated: Sep 1, 2025

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.4K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.2K
Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
06:53

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

5.7K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • New silicon-photomultiplier (SiPM)-based PET/CT systems offer higher detector sensitivity, improving lesion detectability and image quality.
  • This enhanced sensitivity enables reduced acquisition times without compromising diagnostic quality.

Purpose of the Study:

  • To determine the minimum 18F-FDG PET acquisition time for diagnostic quality using phantom imaging.
  • To optimize image reconstruction parameters (algorithm, iterations, voxel size, Gaussian filter) for reduced scan times.
  • To validate phantom findings with patient data.

Main Methods:

  • Utilized three phantoms (soft-tissue tumour, bone-lung tumour, resolution) with clinically relevant lesion characteristics.
  • Acquired PET data on an SiPM-based Biograph Vision PET/CT system, simulating reduced acquisition times (30-300s) from a 10-min scan.
  • Evaluated contrast-to-noise ratio (CNR) and signal deviation against a 10-min reference, with acceptable thresholds set at CNR ≥ 5 and deviation ±20%.

Main Results:

  • An acquisition time of 60 seconds per bed position provided acceptable results for lesions ≥9.7 mm in diameter.
  • Optimal reconstruction involved OSEM-TOF or OSEM-TOF+PSF with a 4-mm Gaussian filter and specific voxel sizes.
  • Patient data confirmed excellent correlation and agreement in lesion quantification between reduced and full acquisition times.

Conclusions:

  • A threefold reduction in PET acquisition time is feasible with SiPM-based systems.
  • Shorter scans can enhance patient comfort or allow for reduced radiation dose.
  • Alternative strategies include reducing applied activity instead of acquisition time.