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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

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Circulating choline pathway nutrients and risk of moyamoya disease

Peicong Ge1,2,3,4,5, Yaobo Zhao1,2, Yuanren Zhai1,2,3,4,5

  • 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Frontiers in Nutrition
|August 18, 2022
PubMed
Abstract

Insights

Higher levels of circulating choline and betaine are linked to a reduced risk of moyamoya disease (MMD) and its subtypes. This suggests a potential protective role for these nutrients in MMD development.

Area of Science:

  • Neurology
  • Nutritional Science
  • Epidemiology

Background:

  • Choline pathway nutrients are crucial for stroke prevention.
  • Limited data exists on the impact of choline and betaine on moyamoya disease (MMD) risk.
  • MMD is a rare cerebrovascular disorder affecting major arteries at the base of the brain.

Purpose of the Study:

  • To investigate the association between serum choline and betaine levels and the incident risk of moyamoya disease (MMD).
  • To examine the relationship between these nutrients and MMD subtypes, including transient ischemic attack (TIA)-type, infarction-type, and hemorrhagic-type MMD.

Main Methods:

  • A case-control study was conducted.
  • Included 385 MMD patients (110 TIA-type, 157 infarction-type, 118 hemorrhagic-type) and 89 matched healthy controls.
  • Serum levels of choline and betaine were measured and analyzed for association with MMD risk.

Main Results:

  • Serum choline and betaine showed an inverse relationship with MMD risk.
  • Increased choline and betaine levels were associated with decreased odds of MMD.
  • The highest quartiles of choline and betaine significantly reduced MMD risk compared to the lowest quartiles.

Conclusions:

  • Serum choline and betaine are associated with a reduced risk of moyamoya disease.
  • These findings highlight a potential neuroprotective role for choline and betaine in MMD.
  • Further research may explore therapeutic interventions targeting choline metabolism for MMD prevention.
Keywords:
betainecholinemoyamoyarisk factorssubtypes

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