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Effect of different feeding methods and gut microbiota on premature infants and clinical outcomes
Manman Liu1, Cheng Chen1, Songhao Kang2
1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Insights
Breastfeeding and formula feeding show no significant differences in clinical outcomes for premature infants. Gut microbiota may play a crucial role in infant development and health.
Area of Science:
- Neonatal care
- Pediatric nutrition
- Microbiome research
Background:
- Premature infants require specialized care, with feeding methods typically including breastfeeding and formula milk.
- Clinical feeding strategies significantly impact infant health and development.
Purpose of the Study:
- To investigate the effects of breastfeeding versus formula milk on clinical outcomes in premature infants.
- To explore the correlation between intestinal flora and clinical indicators in this patient group.
Main Methods:
- Retrospective analysis of premature infants admitted to the neonatal intensive care unit (2017-2018).
- Comparison of feeding methods based on duration of complete enteral feeding, weight gain, and postnatal infections.
- Pearson's correlation coefficient used to assess the relationship between gut microbiota and clinical outcomes.
Main Results:
- No significant differences were observed in clinical indicators between breastfeeding and formula milk groups.
- Neither feeding method demonstrated a significant impact on key clinical indicators.
- Gut microbiota emerged as a potentially important factor influencing clinical outcomes.
Conclusions:
- Current feeding methods (breastfeeding vs. formula) do not show differential effects on clinical outcomes in premature infants.
- The gut microbiota plays a significant role in premature infant care and development.
- Further research into the gut microbiome can inform strategies for promoting healthy development in premature infants.
Abstract:
Premature infants require special care, and clinical feeding methods for this patient group are generally divided into breastfeeding and formula milk. This retrospective study investigated the effects of these two feeding methods on premature infants admitted to the neonatal intensive care unit between 2017 and 2018. Data regarding the duration of complete enteral feeding, weight gain, and postnatal infections were collected, categorized, and compared. Pearson's correlation coefficient was used to determine the correlation between the intestinal flora and clinical outcomes. Results revealed no differences between the two feeding methods, and neither had significant effects on clinical indicators in premature infants, although the gut microbiota may be an important factor influencing many clinical indicators. Results of this study suggest an important role for the gut microbiota in the care of premature infants and provide a basis for promoting the healthy development of this patient population.
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