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Lower esophageal sphincter pressure during the normal menstrual cycle
American Journal of Obstetrics and Gynecology
|May 1, 1979
Summary
Lower esophageal sphincter pressure (LESP) decreases during the luteal phase of the menstrual cycle, coinciding with increased estradiol and progesterone levels. This hormonal shift is associated with a higher incidence of acid reflux in women.
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- Hormonal fluctuations during the menstrual cycle can influence gastrointestinal function.
- The lower esophageal sphincter pressure (LESP) plays a crucial role in preventing acid reflux.
Purpose of the Study:
- To investigate the relationship between menstrual cycle phases, hormonal changes, and lower esophageal sphincter pressure (LESP).
- To assess the incidence of acid reflux in relation to hormonal profiles during different menstrual cycle phases.
Main Methods:
- Measurements of LESP, basal gastric pH, and plasma levels of gastrin, estradiol, and progesterone were taken in ten women during both follicular and luteal phases.
- Acid reflux was evaluated using an intraluminal pH probe during provocative procedures.
Main Results:
- LESP was significantly lower during the luteal phase (16.5 mmHg) compared to the follicular phase (19.0 mmHg).
- Plasma estradiol and progesterone levels were significantly elevated during the luteal phase.
- Acid reflux was detected in five women during the luteal phase versus only one during the follicular phase.
Conclusions:
- Hormonal changes during the luteal phase of the menstrual cycle are associated with decreased LESP.
- The observed decrease in LESP during the luteal phase may contribute to an increased risk of acid reflux.