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Takotsubo cardiomyopathy: A comprehensive review
Walker Barmore1, Himax Patel2, Sean Harrell3
1Department of Internal Medicine, Augusta University Medical Center, Augusta, GA 30912, United States. wabarmore@augusta.edu.
World Journal of Cardiology
|August 18, 2022
Summary
Takotsubo cardiomyopathy (TCM), or stress cardiomyopathy, is a transient heart condition mimicking heart attacks. This review focuses on iatrogenic causes, such as medications and procedures, leading to TCM.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Takotsubo cardiomyopathy (TCM), or stress cardiomyopathy, is characterized by left ventricular dysfunction mimicking myocardial infarction.
- It is triggered by a catecholamine surge from acute physical or emotional stressors.
- While often associated with natural stressors, iatrogenic causes are increasingly recognized.
Purpose of the Study:
- To review and elucidate the iatrogenic causes of Takotsubo cardiomyopathy.
- To highlight the role of medications and procedures in inducing TCM.
- To aid clinicians in prompt recognition and management of iatrogenic TCM.
Main Methods:
- Literature review of reported cases and studies on iatrogenic Takotsubo cardiomyopathy.
- Analysis of specific medications and procedures implicated in TCM development.
- Discussion of the clinical presentation and pathophysiology of iatrogenic TCM.
Main Results:
- Iatrogenic causes of TCM include exogenous catecholamine administration and various medical procedures.
- TCM is a transient condition with generally favorable outcomes.
- Standard cardiomyopathy treatments like beta-blockers and ACE-inhibitors have not shown improved mortality or reduced recurrence in TCM.
Conclusions:
- Prompt recognition of iatrogenic causes is crucial for appropriate clinical management of TCM.
- Supportive measures are typically sufficient for TCM, as it is a transient condition.
- Further research may clarify the specific mechanisms and optimal management strategies for iatrogenic TCM.
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