Related Experiment Video
Updated: Jul 23, 2026
Cloning and Large-Scale Production of High-Capacity Adenoviral Vectors Based on the Human Adenovirus Type 5
Published on: January 28, 2016
Predictive Value of Adenoviral Load for Bronchial Mucus Plugs Formation in Children with Adenovirus Pneumonia
Li Peng1, Silan Liu1, Tian Xie1
1Hunan Provincial Key Laboratory of Pediatric Respirology, Pediatric Medical Center, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410000, China.
Insights
High adenovirus (AdV) load is a significant predictor of bronchial mucus plugs (BMP) in children with AdV pneumonia. This finding helps in early identification and management of BMP in pediatric patients.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Respiratory Medicine
Background:
- Adenovirus (AdV) pneumonia is a common respiratory illness in children.
- Bronchial mucus plugs (BMP) can complicate AdV pneumonia, leading to respiratory distress.
- Identifying risk factors for BMP is crucial for timely intervention.
Purpose of the Study:
- To investigate the risk factors associated with the formation of bronchial mucus plugs (BMP) in children diagnosed with adenovirus (AdV) pneumonia.
- To determine the clinical significance of various factors, including viral load, in predicting BMP development.
Main Methods:
- A retrospective study analyzed 453 children with AdV pneumonia who underwent bronchoscopy.
- Patients were categorized into BMP and control groups.
- Multiple logistic regression, ROC curve analysis, and correlation analysis were employed to identify risk factors.
Main Results:
- 185 out of 453 patients (40.84%) developed BMP.
- Higher incidence of dyspnea, poor spirits, mixed infections, longer fever duration, and elevated CRP, LDH, D-dimer, and AdV load were observed in the BMP group.
- Adenovirus load, Mycoplasma coinfection, D-dimer, fever duration, and LDH were identified as independent risk factors for BMP, with AdV load being the most significant predictor (AUC=0.819).
Conclusions:
- Elevated adenovirus (AdV) load is a key independent risk factor for bronchial mucus plugs (BMP) in children with AdV pneumonia.
- AdV load demonstrates significant clinical value in predicting BMP development.
- These findings can aid in the early detection and management of BMP in pediatric AdV pneumonia.
Background:
The study aimed to explore risk factors for bronchial mucus plugs (BMP) formation in children with adenovirus (AdV) pneumonia.
Methods:
A retrospective study was conducted on children with AdV pneumonia who underwent bronchoscopy from January 2019 to December 2019. Children were divided into the BMP group and the control group, depending on whether BMP was formed or not. The clinical information and treatment proposals of the two groups of children were counted and analyzed via multiple logistic regression analysis, ROC curve analysis, and correlation analysis.
Results:
Among 453 patients with AdV pneumonia, 185 (40.84%) were in the BMP group. Among all the cases, there were 188 patients with a single AdV infection, including 64 (34.04%) in the BMP group and 124 (65.96%) in the control group. The incidence of dyspnea, poor spirits, mixed infections, and other symptoms in the BMP group was higher than in the control group. Children in the BMP group had a longer heat range. C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), and AdV load levels were higher in the MBP group. AdV load, Mycoplasma coinfection, DD, heat range, and LDH were independent risk factors for BMP, among which AdV load was the most significant (AUC = 0.819). AdV load was positively correlated with other risk factors, respectively. AdV load and heat range were independent risk factors for BMP patients with a single AdV infection.
Conclusion:
AdV load might have important clinical value in predicting BMP development in AdV pneumonia.
