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Esophageal granular cell tumor: A case report.
Ya-Lan Chen1, Jing Zhou2, Hui-Ling Yu3
1Department of Gastroenterology, the Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China.
World Journal of Clinical Cases
|August 18, 2022
Summary
Esophageal granular cell tumors (eGCT) are rare neuroectodermal neoplasms. Early diagnosis and endoscopic resection are key to managing eGCT and preventing misdiagnosis.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Esophageal granular cell tumor (eGCT) is a rare, typically benign neuroectodermal neoplasm originating from Schwann cells.
- Clinical presentation is often non-specific, with dysphagia being the most common symptom, frequently leading to misdiagnosis as esophageal polyps.
- eGCT carries a 2% risk of malignant transformation.
Observation:
- A 52-year-old woman presented with symptoms initially diagnosed as "esophageal granuloma" during esophagoscopy.
- This initial diagnosis was incorrect, highlighting challenges in differentiating eGCT from other esophageal conditions.
Findings:
- Definitive diagnosis of eGCT relies on characteristic histopathological findings.
- Immunohistochemical detection of S-100 protein is crucial for confirming eGCT.
- Endoscopic mucosal resection (EMR) is identified as the primary therapeutic approach.
Implications:
- Accurate and timely diagnosis of eGCT is essential to avoid delayed treatment and potential complications.
- Understanding the typical presentation and diagnostic markers can reduce misdiagnosis rates.
- EMR offers a minimally invasive and effective treatment option for solitary eGCTs.
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