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Vitamin E is immunostimulatory in calves.

P G Reddy, J L Morrill, H C Minocha

    Journal of Dairy Science
    |May 1, 1987
    PubMed
    Summary

    Supplemental vitamin E enhances calf immune responses. Supplementing 125 IU/day of vitamin E (alpha-tocopherol) maximized immune function and may be cost-effective for young cattle.

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    Area of Science:

    • Veterinary Immunology
    • Animal Nutrition
    • Ruminant Health

    Background:

    • Vitamin E is a crucial fat-soluble antioxidant vital for immune function.
    • Calves require adequate vitamin E for optimal development and disease resistance.
    • Conventional calf diets may not always provide sufficient vitamin E levels.

    Purpose of the Study:

    • To investigate the impact of supplemental vitamin E on the immune responses of Holstein heifer calves.
    • To determine the optimal dosage of supplemental vitamin E for enhancing calf immunity.
    • To evaluate the effect of vitamin E supplementation on serum cortisol levels and antibody production.

    Main Methods:

    • Thirty-two Holstein heifer calves were divided into four groups, receiving 0, 125, 250, or 500 IU/day of supplemental vitamin E from birth to 24 weeks.
    • Lymphocyte blastogenic responses to T-cell and B-cell mitogens were measured.
    • Serum cortisol concentrations were analyzed.
    • Antibovine herpesvirus type 1 (BoHV-1) antibody titers (IgG) were assessed following vaccination.

    Main Results:

    • Supplemented calves exhibited significantly higher lymphocyte blastogenic responses compared to controls.
    • Mean serum cortisol concentrations were lower in all vitamin E-supplemented groups.
    • Antibody titers following primary vaccination were similar across groups, but a booster response at 24 weeks was higher in calves receiving 125 IU/day vitamin E.
    • The 125 IU/day supplementation level appeared to maximize immune responses.

    Conclusions:

    • Supplemental vitamin E, particularly at 125 IU/day, can enhance cellular and humoral immune responses in young Holstein calves.
    • Vitamin E supplementation may help reduce stress indicators, as evidenced by lower cortisol levels.
    • A daily intake of 125 IU of vitamin E may be the most effective and cost-efficient dose for optimizing calf immunity.

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