Related Experiment Video
Updated: Sep 1, 2025
07:24
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
Published on: January 23, 2018
10.4K
Tranexamic Acid Utilization in Foot and Ankle Surgery: A Meta-analysis
Motasem Salameh1, Ahmed Khalil Attia2, Suhaib El Khatib3
1Department of Orthopedic Surgery, the Warren Alpert Medical School at Brown University, Providence, RI, USA.
Foot & Ankle International
|August 18, 2022
Summary
Tranexamic acid (TXA) effectively reduces blood loss in foot and ankle surgery. This meta-analysis confirms its safety, showing no increased risk of complications or hemoglobin changes.
Area of Science:
- Orthopaedic Surgery
- Pharmacology
Background:
- Tranexamic acid (TXA) is utilized across orthopaedics to minimize blood loss and complications.
- Its specific application in foot and ankle surgery requires further clarification.
Purpose of the Study:
- To evaluate the efficacy and safety of tranexamic acid (TXA) in foot and ankle surgical procedures.
- To synthesize existing evidence through a meta-analysis.
Main Methods:
- A comprehensive database search was performed for studies up to January 2022.
- Nine studies involving 752 patients were included, comparing TXA use versus control.
- Outcomes assessed included estimated blood loss, hemoglobin change, and overall complications.
Main Results:
- Estimated blood loss was significantly reduced in patients receiving TXA.
- No significant differences were observed in hemoglobin levels or overall complication rates between TXA and control groups.
- Risk of bias was assessed using established critical appraisal tools.
Conclusions:
- TXA is associated with decreased blood loss in foot and ankle surgery.
- The use of TXA does not elevate the risk of thromboembolic events or wound complications.
- TXA demonstrates a favorable safety profile for these procedures.
