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Calcium-Regulating Hormonal System and HMGB1 in Cardiomyopathies

Knarik R Harutyunyan1, Hermine T Abrahamyan1, Satenik H Adamyan1

  • 1Yerevan State Medical University after M. Heratsi, Yerevan, Armenia.

Endocrine, Metabolic & Immune Disorders Drug Targets
|August 18, 2022
PubMed

Insights

Cardiomyopathy patients show elevated calcium regulators like parathyroid hormone (PTH) and HMGB1. This suggests PTH activation may protect the heart by restoring calcium balance, despite HMGB1

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Immunology

Background:

  • Calcium ions are vital for cardiac function, with dysregulation linked to heart disease.
  • The calcium-regulating hormonal system and the inflammatory mediator HMGB1 are implicated in cardiac pathology.

Purpose of the Study:

  • Investigate the cardioprotective role of the calcium-regulating hormonal system in cardiomyopathies.
  • Examine the specific involvement of HMGB1 in these cardiac conditions.

Main Methods:

  • Serum calcium (Ca2+) and inorganic phosphate levels were measured.
  • Parathyroid hormone (PTH), calcitonin, vitamin D, and HMGB1 levels were quantified using ELISA kits.

Main Results:

  • Elevated PTH, calcitonin, phosphate, and HMGB1 were observed in female cardiomyopathy patients.
  • Male patients showed similar trends, with significant increases noted in PTH and phosphate levels.

Conclusions:

  • High HMGB1 levels may contribute to reduced left ventricular function in cardiomyopathy.
  • Activated calcium-regulating systems, indicated by elevated PTH, appear to offer cardioprotective effects by restoring calcium homeostasis.
Abstract

Keywords:
CardiomyopathyHMGB1calcitonincalciumcalcium-regulating hormonal systemparathyroid hormonephosphatevitamin D

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