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Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
Published on: May 29, 2017
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Simplified and accessible [18 F]F-AraG synthesis procedure for preclinical PET
Antonia A Högnäsbacka1, Miguel A Cortés González1, Christer Halldin1
1Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.
Journal of Labelled Compounds & Radiopharmaceuticals
|August 18, 2022
Abstract:
The PET tracer [18 F]F-AraG, an arabinosyl guanine analog, has shown promise for visualizing activated T cells in multiple diseases. Herein, a practitioner's protocol is described, in which the PET tracer is prepared using minimal equipment and manual actions, making it widely accessible for preclinical applications.
Keywords:
AraGSPE purification, T cell imaging[18F]F-AraGnucleophilic fluorinationnucleophilic substitutionpractitioner's protocol
