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Updated: Sep 1, 2025
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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Epidemiological characteristics and pathological changes of primary glomerular diseases
Yan Li1, XiaoYang Yu1, WenJing Zhang1
1Nephrology Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Plos One
|August 18, 2022
Summary
Primary glomerular disease predominantly affects middle-aged men, with nephrotic syndrome as the most common clinical sign. Over two decades, the average patient age and nephrotic syndrome prevalence increased, with membranous nephropathy becoming the leading pathological type.
Area of Science:
- Nephrology
- Pathology
- Epidemiology
Background:
- Primary glomerular diseases (PGDs) represent a significant cause of kidney damage.
- Understanding the epidemiological and pathological trends of PGDs is crucial for public health and clinical management.
- Regional data is essential for national kidney disease big data initiatives.
Purpose of the Study:
- To analyze the epidemiological and pathological characteristics of primary glomerular disease over a 20-year period.
- To identify trends in clinical manifestations and pathological types of PGDs.
- To provide regional data for national kidney disease research.
Main Methods:
- Retrospective analysis of 9448 patients (≥18 years) with PGDs undergoing renal biopsy from 2000-2019.
- Patients were grouped into four 5-year intervals for comparative analysis.
- Data on demographics, clinical manifestations, and pathological types were collected and analyzed.
Main Results:
- The study population was predominantly male (1.53:1 ratio), with an increasing proportion of males over time.
- The median age was 41.39 years, with a significant age increase over the study period (P <0.001).
- Nephrotic syndrome was the most common clinical manifestation, increasing in prevalence over time (40.08% to 53.69%).
- Pathological types shifted from mesangial proliferative glomerulonephritis (2000-2009) to IgA nephropathy (2010-2014) and finally to membranous nephropathy (2015-2019).
Conclusions:
- Primary glomerular disease primarily affects middle-aged individuals, with a male predominance.
- Trends indicate an aging patient population and a rising incidence of nephrotic syndrome.
- Membranous nephropathy has emerged as the most prevalent pathological type in recent years, highlighting a significant shift in PGD landscape.
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