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Related Experiment Video

Updated: Aug 31, 2025

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Interrater reliability of deep brain stimulation electrode localizations.

Roxanne Lofredi1, Cem-Georg Auernig2, Siobhan Ewert2

  • 1Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany.

Neuroimage
|August 18, 2022
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Summary

Lead-DBS software ensures reliable deep brain stimulation electrode localization. Manual refinements by different raters show high interrater reliability, validating its ease-of-use for imaging research.

Keywords:
Deep brain stimulationLead-DBSLocalizationParkinson's diseaseSubthalamic nucleus

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Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Computational Neuroscience

Background:

  • Lead-DBS is a widely used open-source software for precise deep brain stimulation (DBS) electrode localization.
  • Previous studies validated automated preprocessing, but manual refinement interrater reliability remained unassessed.

Purpose of the Study:

  • To objectify interrater reliability in manual DBS electrode localization using Lead-DBS.
  • To compare the performance of trainees and experienced raters.
  • To assess localization variance based on imaging modality (CT/MRI) and spatial normalization.

Main Methods:

  • Investigated interrater reliability of manual Lead-DBS electrode localization refinements.
  • Compared localization accuracy between novice trainees and experienced raters.
  • Analyzed localization differences using postoperative CT and MRI, with and without normalization to standard stereotactic space.

Main Results:

  • All raters achieved similar localization results, with average differences between 0.52-0.75 mm.
  • Postoperative MRI and normalization to standard space introduced minor increases in variability (0.07-0.12 mm).
  • Trainees and experienced raters demonstrated comparable performance.

Conclusions:

  • Manual electrode localization using Lead-DBS exhibits high interrater reliability.
  • The findings support Lead-DBS as a reliable and user-friendly tool for DBS imaging research.
  • Results may inform formal training protocols for Lead-DBS users.