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Related Concept Videos

Pipe Flowrate Measurement01:28

Pipe Flowrate Measurement

790
In pipe flow measurement, orifice, nozzle, and Venturi meters are commonly used to determine fluid flowrates by constricting the flow area, which increases fluid velocity and reduces pressure. This pressure difference, governed by Bernoulli's principle and adjusted for real-world conditions, is essential for calculating flowrate. Each meter type is suited to specific applications based on accuracy, efficiency, and compatibility with various flow conditions.
The orifice meter is a simple,...
790
Glassware Calibration01:11

Glassware Calibration

411
Accurate calibration of glassware, such as volumetric flasks, pipettes, and burettes, is essential to ensure accurate measurements in the analytical laboratory. Calibration helps maintain consistency across measurements and prevents errors arising from inaccurate volumes.
Volumetric flasks: Volumetric flasks are designed to prepare aqueous solutions of precise volumes accurately with a calibration line on the neck. To calibrate a volumetric flask, it is important to fill it with distilled...
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Data Validation01:15

Data Validation

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Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
224
Pipe Flowrate Measurement: Problem Solving01:28

Pipe Flowrate Measurement: Problem Solving

597
A spray tank system is engineered to uniformly distribute a pest-control liquid across plants by using a pressurized mechanism. The tank, pressurized to 150 kPa, holds the pesticide at a height of 0.80 meters. Liquid flows from the tank through a 1.9 meter pipe with a diameter of 0.015 meters, angled at 0.698 radians, ultimately reaching a 0.007 meter nozzle that sprays the pesticide. Accurate calculation of the system's flow rate is crucial to ensure uniform application, and this is...
597
Laminar Flow: Problem Solving01:24

Laminar Flow: Problem Solving

243
Laminar flow occurs when a fluid moves smoothly in parallel layers with minimal mixing and turbulence. In fluid mechanics, ensuring laminar flow within a pipe is essential for precise control of flow characteristics, especially in engineering applications. The key factor in determining whether flow remains laminar is the Reynolds number, a dimensionless quantity that depends on the fluid's velocity, density, viscosity, and the pipe's diameter. A Reynolds number of 2100 or lower...
243

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Related Experiment Video

Updated: Aug 31, 2025

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays
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Calibration methods for flow rates down to 5 nL/min and validation methodology.

Chris Mills1, Elsa Batista2, Hugo Bissig3

  • 1TÜV SÜD National Engineering Laboratory, Glasgow, Scotland.

Biomedizinische Technik. Biomedical Engineering
|August 18, 2022
PubMed
Summary

Accurate micro-flow and nano-flow measurements are crucial for drug delivery devices. This study introduces new traceable calibration methods and presents inter-laboratory results for flow meters and syringe pumps.

Keywords:
comparisonflow metermeasurementmicro-flownano-flowtraceabilityuncertainty

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Area of Science:

  • Metrology
  • Biomedical Engineering
  • Fluid Dynamics

Background:

  • Accurate measurement of volume, flow, and pressure is vital for drug delivery devices, especially at low flow rates.
  • Existing metrological infrastructure requires expansion for micro-flow and nano-flow measurements.

Purpose of the Study:

  • To investigate new traceable techniques for micro-flow and nano-flow rate measurements.
  • To expand metrological capabilities for low flow rate applications in medical devices.

Main Methods:

  • Development of new calibration methods for micro-flow and nano-flow rates.
  • Inter-laboratory comparison involving nine laboratories.
  • Calibration of two distinct flow meters and a syringe pump.

Main Results:

  • Demonstration of traceable techniques for flow rate measurement from 5 nL/min to 1,500 nL/min.
  • Presentation of inter-comparison results for flow meter and syringe pump calibration.
  • Validation of new methods through multi-laboratory participation.

Conclusions:

  • New traceable calibration methods are essential for accurate low flow rate measurements.
  • Expanded metrological infrastructure is needed to support advanced drug delivery systems.
  • Inter-laboratory comparisons confirm the reliability of the developed techniques.