Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

105
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
105
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

60
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
60
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

76
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
76
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

5.7K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.7K
Real Time RT-PCR02:57

Real Time RT-PCR

58.5K
Real-time reverse transcription-polymerase chain reaction, or Real-time RT-PCR, is an analytical tool used to determine the expression level of target genes. The method involves converting mRNA to complementary DNA with the help of an enzyme known as reverse transcriptase, followed by the PCR amplification of the cDNA. These two processes can be performed simultaneously in a single tube or separately as a two-step reaction.
The real-time quantification of the number of amplified products is...
58.5K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

42
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
42

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between the triglyceride-glucose index and kidney stone disease: a systematic review and dose-response meta-analysis.

Lipids in health and disease·2026
Same author

Metabolic complications of citrate anticoagulation in continuous renal replacement therapy (crrt): a delphi consensus on indications, monitoring and management.

Critical care (London, England)·2026
Same author

Should we change our approach to detecting citrate accumulation in patients treated with CRRT with regional citrate?

Critical care (London, England)·2026
Same author

Bridging the Gap: A Needs Assessment of Resources and Support for International Medical Graduates Navigating Visa-related Career Decisions in Infectious Diseases.

Open forum infectious diseases·2026
Same author

Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial.

The Lancet. Respiratory medicine·2026
Same author

Key Performance Indicators for Acute Intermittent Renal Replacement Therapy in Critically Ill Patients: A Systematic Review.

Blood purification·2026

Related Experiment Video

Updated: Aug 31, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K

Continuous KRT: A Contemporary Review.

J Pedro Teixeira1, Javier A Neyra2,3, Ashita Tolwani3

  • 1Divisions of Nephrology and Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.

Clinical Journal of the American Society of Nephrology : CJASN
|August 18, 2022
PubMed
Summary
This summary is machine-generated.

Continuous Renal Replacement Therapy (CRRT) offers kidney support for critically ill patients with Acute Kidney Injury (AKI). Standardizing CRRT prescription and delivery is crucial for improving patient outcomes in critical care settings.

More Related Videos

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

8.2K
The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
14:56

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

9.1K

Related Experiment Videos

Last Updated: Aug 31, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

8.2K
The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
14:56

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

9.1K

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Intensive Care Unit (ICU) Management

Background:

  • Acute Kidney Injury (AKI) is a frequent and severe complication in critically ill patients, significantly increasing morbidity and mortality.
  • Continuous Renal Replacement Therapy (CRRT) is a preferred dialysis modality for hemodynamically unstable patients with AKI.
  • Current CRRT application shows significant variability due to a lack of standardized protocols for prescription, delivery, and optimization.

Approach:

  • This manuscript provides a comprehensive overview of CRRT, encompassing recent clinical trials and outcome studies.
  • It reviews essential aspects of CRRT, including indications, technical considerations, and management strategies.
  • The review highlights the importance of multidisciplinary collaboration and quality assurance for effective CRRT delivery.

Key Points:

  • CRRT modalities differ in solute transport mechanisms and fluid management strategies.
  • Key technical aspects include vascular access, CRRT dosing, anticoagulation, and nutritional support.
  • Management of CRRT complications is critical for patient safety and treatment efficacy.

Conclusions:

  • Standardization of CRRT protocols is essential to improve patient outcomes in critical care.
  • Effective CRRT requires a collaborative, multidisciplinary team approach.
  • Development of robust quality assurance programs is necessary for high-quality CRRT provision.